Highlanders five-eighth Lima Sopoaga and Hurricanes lock James Broadhurst will make their All Blacks Test debuts against the Springboks in Johannesburg on Saturday.
Sopoaga comes in for Daniel Carter at No.10 while Broadhurst replaces Luke Romano.
In other changes from the line-up which won last week's Rugby Championship clash against Argentina 39-18, Dane Coles comes in at hooker and Liam Messam at blindside flanker.
Aaron Smith returns at halfback, and Ma'a Nonu and Conrad Smith's long-standing partnership is reprised in the midfield.
Israel Dagg again starts at fullback with Ben Smith named on the right wing.